OperaV1, Main, Exploration, bibRecord, 000048

Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

Identifieur interne : 000048 ( Main/Exploration ); précédent : 000047; suivant : 000049

Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

Auteurs : Tue Wenzel Kragstrup [Danemark] ; Babak Jalilian [Danemark] ; Kresten Krarup Keller [Danemark] ; Xianwei Zhang [Danemark] ; Julie Kristine Laustsen [Danemark] ; Kristian Stengaard-Pedersen [Danemark] ; Merete Lund Hetland [Danemark] ; Kim H Rslev-Petersen [Danemark] ; Peter Junker [Danemark] ; Mikkel Stergaard [Danemark] ; Ellen-Margrethe Hauge [Danemark] ; Malene Hvid [Danemark] ; Thomas Vorup-Jensen [Danemark] ; Bent Deleuran [Danemark]

Source :

PloS one ; 2016.

RBID : pubmed:26849368

Abstract

In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies remain poorly understood. We have previously reported low levels of the soluble form of CD18 (sCD18) in plasma from patients with chronic RA and spondyloarthritis. Here, we study the changes of sCD18 before and during treatment of early RA and following arthritis induction in murine models of rheumatoid arthritis.

DOI: 10.1371/journal.pone.0148486
PubMed: 26849368

Affiliations:

Danemark

Le document en format XML

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<author><name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
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<author><name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
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<author><name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel  Stergaard</name>
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<author><name sortKey="Hauge, Ellen Margrethe" sort="Hauge, Ellen Margrethe" uniqKey="Hauge E" first="Ellen-Margrethe" last="Hauge">Ellen-Margrethe Hauge</name>
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<author><name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
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</author>
<author><name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name>
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<front><div type="abstract" xml:lang="en">In rheumatoid arthritis (RA) immune activation and presence of autoantibodies may precede clinical onset of disease, and joint destruction can progress despite remission. However, the underlying temporal changes of such immune system abnormalities in the inflammatory response during treat-to-target strategies remain poorly understood. We have previously reported low levels of the soluble form of CD18 (sCD18) in plasma from patients with chronic RA and spondyloarthritis. Here, we study the changes of sCD18 before and during treatment of early RA and following arthritis induction in murine models of rheumatoid arthritis.</div>
</front>
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<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
<name sortKey="Hauge, Ellen Margrethe" sort="Hauge, Ellen Margrethe" uniqKey="Hauge E" first="Ellen-Margrethe" last="Hauge">Ellen-Margrethe Hauge</name>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
<name sortKey="Jalilian, Babak" sort="Jalilian, Babak" uniqKey="Jalilian B" first="Babak" last="Jalilian">Babak Jalilian</name>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
<name sortKey="Keller, Kresten Krarup" sort="Keller, Kresten Krarup" uniqKey="Keller K" first="Kresten Krarup" last="Keller">Kresten Krarup Keller</name>
<name sortKey="Laustsen, Julie Kristine" sort="Laustsen, Julie Kristine" uniqKey="Laustsen J" first="Julie Kristine" last="Laustsen">Julie Kristine Laustsen</name>
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Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

Changes in Soluble CD18 in Murine Autoimmune Arthritis and Rheumatoid Arthritis Reflect Disease Establishment and Treatment Response.

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Abstract

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